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promethazine and daridorexant both of those boost sedation. Modify Therapy/Keep an eye on Carefully. Coadministration increases risk of CNS despair, which can lead to additive impairment of psychomotor effectiveness and trigger daytime impairment.promethazine improves effects of daxibotulinumtoxinA by pharmacodynamic synergism. Use Caution/Observe.